Malegra’s mechanism of action revolves around the inhibition of the enzyme PDE-5 (phosphodiesterase type 5). In a healthy, sexually active individual, the release of nitric oxide during arousal triggers the production of camp, a substance that relaxes the smooth muscles in the penis and allows blood to flow freely. PDE-5 typically breaks down camp, limiting blood flow and resulting in difficulties achieving an erection. Sildenafil, the active ingredient in Malegra, inhibits the action of PDE-5, thereby increasing the levels of camp in the penis. This allows for enhanced blood flow, leading to a firmer, longer-lasting erection when the individual is sexually stimulated.

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